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Article

Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement.

Neuron - 6 Oct 2010

Carrillo Robert A, Olsen Douglas P, Yoon Kenneth S, Keshishian Haig

Abstract excerpt

Establishing synaptic connections often involves the activity-dependent withdrawal of off-target contacts. We describe an in vivo role for temporally patterned electrical activity, voltage-gated calcium channels, and CaMKII in modulating the response of Drosophila motoneurons to the chemorepellent Sema-2a during synaptic refinement. Mutations affecting the Sema-2a ligand, the plexin B receptor (plexB), the...

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Identifiers

PMID: 20920789
DOI: 10.1016/j.neuron.2010.09.005
PMCID: PMC2950831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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