Article
Association between -238 but not -308 polymorphism of Tumor necrosis factor alpha (TNF-alpha)v and unexplained recurrent spontaneous abortion (URSA) in Chinese population.
Reproductive biology and endocrinology : RB&E - 28 Sept 2010
Liu Chunmei, Wang Jing, Zhou Sirui, Wang Binbin, Ma Xu
Abstract excerpt
OBJECTIVES: TNF-alpha is a critical cytokine produced by Th1 cells while altered T helper 1 (Th1)-Th2 balance is found crucial for a successful pregnancy. STUDY DESIGN: A cohort of 132 Southern Chinese Han RSA patients and 152 controls constituted the subjects of this study. Two functional polymorphisms -308 and -238 of TNF-alpha were studied by association analysis. RESULTS: lack of association was found in...
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