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Article

Nutritional requirements of wild-type and folate transport-deficient Leishmania donovani for pterins and folates.

Molecular and biochemical parasitology - 1 Dec 1990

Beck J T, Ullman B

Abstract excerpt

The nutritional requirements for folates and pterins were assessed for two strains of Leishmania donovani promastigotes, a wild-type (D1700) parental strain and a mutant derivative (MTXA5) which possesses a markedly diminished capacity to transport both [3H]folate and [3H]methotrexate (MTX). Both L. donovani strains have an absolute growth requirement for an exogenous pterin, since their proliferation could not...

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PMID: 2090944
DOI: 10.1016/0166-6851(90)90147-e

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