Article
A copy number repeat polymorphism in the transactivation domain of the CEPBA gene is possibly associated with a protective effect against acquired CEBPA mutations: an analysis in 1135 patients with AML and 187 healthy controls.
Experimental hematology - 1 Jan 2011
Schnittger Susanne, Bacher Ulrike, Eder Christiane, Lohse Peter, Haferlach Claudia, Kern Wolfgang, Haferlach Torsten
Abstract excerpt
OBJECTIVE: CEBPA-mutated normal karyotype acute myeloid leukemia (AML) has recently been included as a provisional entity in the World Health Organization classification. The CEBPA mutations are heterogeneous, including missense/nonsense base exchanges, frameshift mutations, and insertions/deletions being distributed throughout the gene. One of the genetic alterations within CEBPA (c.1175_1180dup; p.P194_H195dup)...
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