Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.

doi:10.1002/ajmg.b.31126

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Article

Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2010

Winterer Georg, Mittelstrass Kirstin, Giegling Ina, Lamina Claudia, Fehr Christoph, Brenner Hermann, Breitling Lutz P, Nitz Barbara, Raum Elke, Müller Heiko, Gallinat Jürgen, Gal Andreas, Heim Katharina, Prokisch Holger, Meitinger Thomas, Hartmann Annette M, Möller Hans-Jürgen, Gieger Christian, Wichmann H-Erich, Illig Thomas, Dahmen Norbert, Rujescu Dan

Abstract excerpt

Recent studies strongly support an association of the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 with nicotine dependence (ND). However, the precise genotype-phenotype relationship is still unknown. Clinical and epidemiological data on smoking behavior raise the possibility that the relevant gene variants may indirectly contribute to the development of ND by affecting cognitive performance...

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Identifiers

PMID: 20886544
DOI: 10.1002/ajmg.b.31126

Genes

CHRNA5
CHRNA3
CHRNB4

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Source receipt: pubmed, retrieved 7 Sept 2026.

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