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Article

Manipulation of valve composition to elucidate the role of collagen in aortic valve calcification.

BMC cardiovascular disorders - 1 Mar 2014

Rodriguez Karien J, Piechura Laura M, Porras Ana M, Masters Kristyn S

Abstract excerpt

BACKGROUND: Extracellular matrix (ECM) disarray is found in calcific aortic valvular disease (CAVD), yet much remains to be learned about the role of individual ECM components in valvular interstitial cell (VIC) function and dysfunction. Previous clinical analyses have shown that calcification is associated with decreased collagen content, while previous in vitro work has suggested that the presence of collagen...

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Identifiers

PMID: 24581344
DOI: 10.1186/1471-2261-14-29
PMCID: PMC3946110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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