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Article

Role of the MAPK/ERK pathway in valvular interstitial cell calcification.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2009

Gu Xiaoxiao, Masters Kristyn S

Abstract excerpt

Much remains to be discovered about the etiology of heart valve disease and the molecular level mechanisms that drive it. The MAPK/ERK pathway influences calcification in many cell types and has been linked to the expression of a contractile phenotype in valvular interstitial cells (VICs). However, a direct correlation between MAPK/ERK pathway activity and VIC calcification has not been previously described. Thus...

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Identifiers

PMID: 19363136
DOI: 10.1152/ajpheart.00099.2009
PMCID: PMC5243218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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