Article
B-RAF: A contributor to the melanoma phenotype.
The international journal of biochemistry & cell biology - 1 Jan 2011
Heath E M L, Kaufman K L, Christopherson R I
Abstract excerpt
B-RAF, a serine-threonine protein kinase, is one of the three RAF paralogs in humans. B-RAF participates in the RAS-RAF-MEK-ERK pathway, a conserved protein kinase-signalling cascade that is involved in regulating a number of critical cellular functions. Mutated B-RAF is believed to play a crucial role in the development, maintenance and progression of melanoma, where it contributes to multiple aspects of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.