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Article

Long-term efavirenz autoinduction and its effect on plasma exposure in HIV patients.

Clinical pharmacology and therapeutics - 1 Nov 2010

Ngaimisi E, Mugusi S, Minzi O M, Sasi P, Riedel K-D, Suda A, Ueda N, Janabi M, Mugusi F, Haefeli W E, Burhenne J, Aklillu E

Abstract excerpt

We investigated the influence of gender and pharmacogenetic variations on long-term efavirenz autoinduction and disposition among patients with HIV in Tanzania (N = 129). Plasma concentrations (at 16 h) of efavirenz and 8-hydroxyefavirenz were quantified at weeks 4 and 16 of therapy. Genotyping was performed to identify cytochrome P450 (CYP) 2B6*6, CYP3A5*3, *6, and *7, and ABCB1-3435 C/T genotypes. There were...

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Identifiers

PMID: 20881953
DOI: 10.1038/clpt.2010.172

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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