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Article

Induction of Multiple Drug Transporters by Efavirenz

1 Jan 2009

Abstract excerpt

Efavirenz, an important component of human immunodeficiency virus 1 (HIV-1) therapy, causes substantial drug interactions as an inducer of cytochromes and the transporter ABCB1. So far its effect on the expression of other transporters is unknown. We therefore investigated the effect of long-term exposure of cells to efavirenz on expression of a large number of important drug transporters and on cell...

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PMID: 19234366
DOI: 10.1254/jphs.08209fp

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