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Article

Genetic risk markers for nasopharyngeal carcinoma in Portugal: tumor necrosis factor alpha -308G >A polymorphism.

DNA and cell biology - 1 Feb 2011

Sousa Hugo, Breda Eduardo, Santos Alexandra M, Catarino Raquel, Pinto Daniela, Medeiros Rui

Abstract excerpt

The tumor necrosis factor-alpha (TNF-α) is a strong proinflammatory cytokine produced by the activated macrophages in the immune response to viral infections. A common polymorphism on the promoter region of TNFA gene (-308G >A) has been associated with different susceptibilities to the development of several diseases including viral-associated neoplasias. Data suggest that the A allele has been associated with...

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Identifiers

PMID: 20874489
DOI: 10.1089/dna.2010.1086

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TNF

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