Article
Association of -308 TNF-α promoter polymorphism with clinical aggressiveness in patients with head and neck squamous cell carcinoma.
Oral oncology - 1 Sept 2011
Corrêa Gefter Thiago Batista, Bandeira Gabriela Alencar, Cavalcanti Bruna Gonçalves, de Carvalho Fraga Carlos Alberto, dos Santos Erivelton Pereira, Silva Thiago Fonseca, Gomez Ricardo Santiago, Guimarães André Luiz Sena, De Paula Alfredo Maurício Batista
Abstract excerpt
Genetic polymorphisms in the promoter region of the tumour necrosis factor-α (TNF-α) gene are involved in the regulation of the expression levels of its cytokine. Besides, these polymorphisms have been associated with the clinical behaviour of cancer. We investigated the -308 promoter region polymorphisms of the TNF-α gene and its association with the clinicopathological factors of a head and neck squamous cell...
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