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Article

Diminution of eIF4E activity suppresses parkin mutant phenotypes.

Gene - 1 Jan 2011

Ottone Cristina, Galasso Alessia, Gemei Marica, Pisa Viviana, Gigliotti Silvia, Piccioni Federica, Graziani Franco, Verrotti di Pianella Arturo

Abstract excerpt

Mutations in the human parkin (PARK2) gene cause autosomal recessive-juvenile Parkinson's disease (AR-JP). In Drosophila melanogaster, mutant parkin alleles display a broad range of phenotypic alterations, including female infertility. Here we report that reducing the level of eukaryotic translation initiation factor 4E (eIF4E) activity specifically rescues the female sterile phenotypes associated with the...

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PMID: 20869429
DOI: 10.1016/j.gene.2010.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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