Article
An inducible nitric oxide synthase polymorphism is associated with the risk of recurrent depressive disorder.
Neuroscience letters - 17 Dec 2010
Gałecki Piotr, Maes Michael, Florkowski Antoni, Lewiński Andrzej, Gałecka Elżbieta, Bieńkiewicz Małgorzata, Szemraj Janusz
Abstract excerpt
Evidence indicates that depressive disorder is a heterogenic disease, and oxidative stress, inflammation and impairment of neurogenesis play a role in its aetiology. Moreover, there are data suggesting that genetic factors affect the development of depression. Nitric oxide (NO) is a biological molecule with both a beneficial and a detrimental role in brain. One of the three enzymes generating NO is inducible...
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