Article
Association analysis for neuronal nitric oxide synthase gene polymorphism with major depression and fluoxetine response.
Neuropsychobiology - 1 Jan 2003
Yu Younger W-Y, Chen Tai-Jui, Wang Ying-Chieh, Liou Ying-Jay, Hong Chen-Jee, Tsai Shih-Jen
Abstract excerpt
Nitric oxide (NO) is produced from its precursor L-arginine by the enzyme NO synthase (NOS), which includes at least three distinct isoforms - neuronal (nNOS), endothelial, and inducible NOS. Recent studies have implicated NOS in the mechanism that underlies the therapeutic efficacy of antidepres...
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