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Article

The Stringent Response Is Required for Full Virulence of<i>Mycobacterium tuberculosis</i>in Guinea Pigs

23 Sept 2010

Abstract excerpt

During human latent tuberculosis infection, Mycobacterium tuberculosis likely resides within the nutrient‐starved environment of caseous lung granulomas. The stringent response alarmone (p)ppGpp is synthesized by Rel in response to nutrient starvation, thus enabling tubercle bacilli to restrict growth and shut down metabolism in a coordinated fashion. In this study, we investigated the virulence of a...

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PMID: 20863231
DOI: 10.1086/656524

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