Deletion of a<i>Mycobacterium tuberculosis</i>Proteasomal ATPase Homologue Gene Produces a Slow‐Growing Strain That Persists in Host Tissues

Abstract excerpt

The in vivo rate of proliferation of Mycobacterium tuberculosis, the causative agent of tuberculosis, has been linked to the rate of progression and severity of disease. Here, we report that deletion of the gene MT2175 (Rv2115c), a putative mycobacterial proteasome-associated AAA-ATPase, leads to a reduction in the growth rate of M. tuberculosis in vitro and in vivo. Despite the reduced growth, the mutant...

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