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Requirement of the<i>mymA</i>Operon for Appropriate Cell Wall Ultrastructure and Persistence of<i>Mycobacterium tuberculosis</i>in the Spleens of Guinea Pigs

3 Jun 2005

Abstract excerpt

We had recently reported that the mymA operon (Rv3083 to Rv3089) of Mycobacterium tuberculosis is regulated by AraC/XylS transcriptional regulator VirS (Rv3082c) and is important for the cell envelope of M. tuberculosis. In this study, we further show that a virS mutant (MtbdeltavirS) and a mymA mutant (Mtbmym::hyg) of M. tuberculosis exhibit reduced contents and altered composition of mycolic acids along with...

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Identifiers

PMID: 15937179
DOI: 10.1128/jb.187.12.4173-4186.2005

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