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Article

Analysis of population structure: a unifying framework and novel methods based on sparse factor analysis.

PLoS genetics - 16 Sept 2010

Engelhardt Barbara E, Stephens Matthew

Abstract excerpt

We consider the statistical analysis of population structure using genetic data. We show how the two most widely used approaches to modeling population structure, admixture-based models and principal components analysis (PCA), can be viewed within a single unifying framework of matrix factorization. Specifically, they can both be interpreted as approximating an observed genotype matrix by a product of two...

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Identifiers

PMID: 20862358
DOI: 10.1371/journal.pgen.1001117
PMCID: PMC2940725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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