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Article

Probabilistic models of genetic variation in structured populations applied to global human studies.

Bioinformatics (Oxford, England) - 1 Mar 2016

Hao Wei, Song Minsun, Storey John D

Abstract excerpt

MOTIVATION: Modern population genetics studies typically involve genome-wide genotyping of individuals from a diverse network of ancestries. An important problem is how to formulate and estimate probabilistic models of observed genotypes that account for complex population structure. The most prominent work on this problem has focused on estimating a model of admixture proportions of ancestral populations for...

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PMID: 26545820
DOI: 10.1093/bioinformatics/btv641
PMCID: PMC4795615

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