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Article

Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4.

Journal of lipid research - 1 Jan 2011

Vezeridis Alexander M, Drosatos Konstantinos, Zannis Vassilis I

Abstract excerpt

We have used adenovirus-mediated gene transfer in apolipoprotein (apo)E(-/-) mice to elucidate the molecular etiology of a dominant form of type III hyperlipoproteinemia (HLP) caused by the R142C substitution in apoE4. It was found that low doses of adenovirus expressing apoE4 cleared cholesterol, whereas comparable doses of apoE4[R142C] greatly increased plasma cholesterol, triglyceride, and apoE levels, caused...

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Share to Apolipoprotein E4
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Phosphatidylcholine-Sterol O-Acyltransferase

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Source

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Identifiers

PMID: 20861163
DOI: 10.1194/jlr.M008409
PMCID: PMC2999928

Genes

LCAT
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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