Article
Cis-acting regulatory variation in the human genome.
Science (New York, N.Y.) - 22 Oct 2004
Pastinen Tomi, Hudson Thomas J
Abstract excerpt
The systematic screening of the human genome for genetic variants that affect gene regulation should advance our fundamental understanding of phenotypic diversity and lead to the identification of alleles that modify disease risk. There are several challenges in localizing regulatory polymorphisms, including the wide spectrum of cis-acting regulatory mechanisms, the inconsistent effects of regulatory variants in...
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