The <i>miR-17-92</i> Cluster of MicroRNAs Confers Tumorigenicity by Inhibiting Oncogene-Induced Senescence

Abstract excerpt

In mammalian cells, activation of oncogenes usually triggers innate tumor-suppressing defense mechanisms, including apoptosis and senescence, which are compromised by additional mutations before cancers are developed. The miR-17-92 gene cluster, a polycistron encoding six microRNAs (miRNA), is frequently overexpressed in human cancers and has been shown to promote several aspects of oncogenic transformation,...

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