miR-20a regulates expression of the iron exporter ferroportin in lung cancer

Abstract excerpt

MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression by base pairing to partially complementary sites within the 3′-untranslated regions (3′UTR) of target messenger RNAs (mRNA) [ 1 ]. Binding of miRNA to its target mRNA causes translation repression [ 2 ] and/or mRNA degradation [ 3 ]. Genome-wide profiling of miRNA expression in cancer samples and their corresponding...

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