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Article

The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition

14 Aug 2008

Abstract excerpt

BACKGROUND: MicroRNAs are modifiers of gene expression, acting to reduce translation through either translational repression or mRNA cleavage. Recently, it has been shown that some microRNAs can act to promote or suppress cell transformation, with miR-17-92 described as the first oncogenic microRNA. The association of miR-17-92 encoded microRNAs with a surprisingly broad range of cancers not only underlines the...

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PMID: 18700987
DOI: 10.1186/gb-2008-9-8-r127

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