Article
CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells.
Biochemical and biophysical research communications - 22 Oct 2010
Kajihara Ryutaro, Fukushige Shota, Shioda Norifumi, Tanabe Kano, Fukunaga Kohji, Inui Seiji
Abstract excerpt
Protein phosphatase (PP) 6 is a serine threonine phosphatase which belongs to the PP2A subfamily of protein phosphatases. PP6 has been implicated in the control of apoptosis. A dominant negative form PP6 (DN-PP6) mutant cDNA was prepared and transfected into HeLa cells to investigate the regulation of apoptosis. HeLa cells expressing DN-PP6 showed increased resistance to apoptosis induced by TNF and...
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