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Mitogen-activated protein kinase phosphatase 1 is involved in tamoxifen resistance in MCF7 cells

2 Sept 2015

Abstract excerpt

Tamoxifen resistance is a major clinical problem for ER-positive breast cancer, but the underlying mechanism is not completely elucidated. In the present study, we reported that mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1), a member of the family of MKPs, is involved in tamoxifen resistance. We found that MKP1 expression increased in tamoxifen resistant MCF7 cells. To explore the possible role of...

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PMID: 26329166
DOI: 10.3892/or.2015.4244

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