Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population.

doi:10.1016/j.ijid.2010.05.020

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Article

Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Nov 2010

Deschamps Romain, Béra Odile, Belrose Gilda, Lezin Agnès, Bellance Rémi, Signate Aissatou, Cabre Philippe, Smadja Didier, Césaire Raymond, Olindo Stephane

Abstract excerpt

OBJECTIVES: Human T-cell lymphotropic virus type 1 (HTLV-1) infection leads to the risk of developing HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) in less than 5% of cases. The mechanism of disease progression in HAM/TSP remains unknown. A significant role of certain human leukocyte antigen (HLA) genotypes in determining the risk of HAM/TSP has been reported in Japan, where the HLA-A*02...

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PMID: 20851016
DOI: 10.1016/j.ijid.2010.05.020

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