Article
CALHM1 P86L polymorphism is associated with late-onset Alzheimer's disease in a recessive model.
Journal of Alzheimer's disease : JAD - 1 Jan 2010
Boada Mercè, Antúnez Carmen, López-Arrieta Jesús, Galán José Jorge, Morón Francisco J, Hernández Isabel, Marín Juan, Martínez-Lage Pablo, Alegret Montserrat, Carrasco Jose M, Moreno Concha, Real Luis M, González-Pérez Antonio, Tárraga Lluís, Ruiz Agustín
Abstract excerpt
CALHM1 gene coding non-synonymous SNP P86L (rs2986017) was reported to increase the risk of Alzheimer's disease (AD) in a recent study. We have investigated this genetic variant in 2470 individuals from Spain to conduct an independent replication study of the proposed SNP marker. By applying a recessive model, we observed weak evidence of an association between P86L mutation and late-onset AD (LOAD)...
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