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Article

CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.

Neuroscience letters - 22 Jan 2010

Giedraitis Vilmantas, Glaser Anna, Sarajärvi Timo, Brundin RoseMarie, Gunnarsson Malin Degerman, Schjeide Brit-Maren, Tanzi Rudolph E, Helisalmi Seppo, Pirttilä Tuula, Kilander Lena, Lannfelt Lars, Soininen Hilkka, Bertram Lars, Ingelsson Martin, Hiltunen Mikko

Abstract excerpt

Recently, the P86L alteration in CALHM1 (calcium homeostasis modulator-1) was reported to be associated with Alzheimer's disease (AD). Moreover, the risk allele increased amyloid-beta (A beta) levels in conditioned media from cultured cells. Therefore, we hypothesized that CALHM1 P86L may modulate A beta or tau levels in cerebrospinal fluid (CSF). Nearly 200 individuals with AD or other cognitive disorders were...

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Amyloid beta-Peptides
Calcium Channels
Cognition Disorders
Finland
Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20005921
DOI: 10.1016/j.neulet.2009.12.011
PMCID: PMC2860374

Genes

CALHM1

Variants

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CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.PMID 20005921Read ↗

CALHM1 P86L polymorphism modulates CSF Aβ levels in cognitively healthy individuals at risk for Alzheimer's disease.Semantic proximity Read ↗

No association between CALHM1 polymorphism and Alzheimer's disease risk in a Hungarian population.Semantic proximity Read ↗

Lack of association between CALHM1 p.P86L variation and Alzheimer's disease in the Han Chinese population.Semantic proximity Read ↗

Calcium homeostasis modulator 1 gene P86L polymorphism and the risk for alzheimer's disease: A meta-analysis.Semantic proximity Read ↗

CALHM1 variant is not associated with Alzheimer's disease among Asians.Semantic proximity Read ↗

No association between CALHM1 variation and risk of Alzheimer disease.Semantic proximity Read ↗

The P86L common allele of CALHM1 does not influence risk for Alzheimer disease in Japanese cohorts.Semantic proximity Read ↗

Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.Semantic proximity Read ↗

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.Semantic proximity Read ↗

Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer's disease.Semantic proximity Read ↗

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.Semantic proximity Read ↗

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