Article
An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.
Science (New York, N.Y.) - 2 Feb 2007
Rivera Miguel N, Kim Woo Jae, Wells Julie, Driscoll David R, Brannigan Brian W, Han Moonjoo, Kim James C, Feinberg Andrew P, Gerald William L, Vargas Sara O, Chin Lynda, Iafrate A John, Bell Daphne W, Haber Daniel A
Abstract excerpt
Wilms tumor is a pediatric kidney cancer associated with inactivation of the WT1 tumor-suppressor gene in 5 to 10% of cases. Using a high-resolution screen for DNA copy-number alterations in Wilms tumor, we identified somatic deletions targeting a previously uncharacterized gene on the X chromosome. This gene, which we call WTX, is inactivated in approximately one-third of Wilms tumors (15 of 51 tumors). Tumors...
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