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Article

The physical spacing between the von Willebrand factor D'D3 and A1 domains regulates platelet adhesion in vitro and in vivo.

Journal of thrombosis and haemostasis : JTH - 1 Mar 2018

Zhang C, Kelkar A, Nasirikenari M, Lau J T Y, Sveinsson M, Sharma U C, Pokharel S, Neelamegham S

Abstract excerpt

Essentials The role of von Willebrand factor (VWF) domains in regulating platelet adhesion was studied in vivo. Multimeric VWF with spacers at the N- and C-terminus of VWF-A1 were systematically tested. N-terminal modified VWF avidly bound platelet GpIbα, causing VWD Type2B like phenotype in mice. Novel anti-D'D3 mAbs suggest that changes at the D'D3-A1 interface may be biologically relevant. SUMMARY: Background...

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Source

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Identifiers

PMID: 29251812
DOI: 10.1111/jth.13927
PMCID: PMC5826847

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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