Article
Pan-genome sequence analysis using Panseq: an online tool for the rapid analysis of core and accessory genomic regions.
BMC bioinformatics - 15 Sept 2010
Laing Chad, Buchanan Cody, Taboada Eduardo N, Zhang Yongxiang, Kropinski Andrew, Villegas Andre, Thomas James E, Gannon Victor P J
Abstract excerpt
BACKGROUND: The pan-genome of a bacterial species consists of a core and an accessory gene pool. The accessory genome is thought to be an important source of genetic variability in bacterial populations and is gained through lateral gene transfer, allowing subpopulations of bacteria to better adapt to specific niches. Low-cost and high-throughput sequencing platforms have created an exponential increase in genome...
Topics
- DNA, Bacterial
- Escherichia coli
- Escherichia coli O157
- Genome, Bacterial
- Phylogeny
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA
- Software