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Estimating variation within the genes and inferring the phylogeny of 186 sequenced diverse Escherichia coli genomes.

BMC genomics - 31 Oct 2012

Kaas Rolf S, Friis Carsten, Ussery David W, Aarestrup Frank M

Abstract excerpt

BACKGROUND: Escherichia coli exists in commensal and pathogenic forms. By measuring the variation of individual genes across more than a hundred sequenced genomes, gene variation can be studied in detail, including the number of mutations found for any given gene. This knowledge will be useful for creating better phylogenies, for determination of molecular clocks and for improved typing techniques. RESULTS: We...

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PMID: 23114024
DOI: 10.1186/1471-2164-13-577
PMCID: PMC3575317

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