Article
A reference pan-genome approach to comparative bacterial genomics: identification of novel epidemiological markers in pathogenic Campylobacter.
PloS one - 1 Jan 2014
Méric Guillaume, Yahara Koji, Mageiros Leonardos, Pascoe Ben, Maiden Martin C J, Jolley Keith A, Sheppard Samuel K
Abstract excerpt
The increasing availability of hundreds of whole bacterial genomes provides opportunities for enhanced understanding of the genes and alleles responsible for clinically important phenotypes and how they evolved. However, it is a significant challenge to develop easy-to-use and scalable methods for characterizing these large and complex data and relating it to disease epidemiology. Existing approaches typically...
Topics
- Campylobacter
- Campylobacter Infections
- Campylobacter coli
- Campylobacter jejuni
- Genetic Variation
- Genome, Bacterial
- Genomics
- Phylogeny
- Prevalence