Article
Polymorphisms in complement component 3 (C3F) and complement factor H (Y402H) increase the risk of postoperative neurocognitive dysfunction following carotid endarterectomy.
Journal of neurology, neurosurgery, and psychiatry - 1 Mar 2011
Gigante Paul R, Kotchetkov Ivan S, Kellner Christopher P, Haque Raqeeb, Ducruet Andrew F, Hwang Brian Y, Solomon Robert A, Heyer Eric J, Connolly E Sander
Abstract excerpt
BACKGROUND: Up to 28% of patients undergoing carotid endarterectomy (CEA) are estimated to experience neurocognitive dysfunction following surgery. The complement cascade plays a central role in ischaemia-reperfusion injury. The authors investigated the effect of common polymorphisms in the complement component 3 (C3F) and complement factor H (CFH Y402H) genes on incidence of neurocognitive dysfunction post-CEA....
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