Phosphodiesterase 4D single-nucleotide polymorphism 83 and cognitive dysfunction in carotid endarterectomy patients.

doi:10.1227/NEU.0000000000000085

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Article

Phosphodiesterase 4D single-nucleotide polymorphism 83 and cognitive dysfunction in carotid endarterectomy patients.

Neurosurgery - 1 Nov 2013

Heyer Eric J, Mergeche Joanna L, Ward Justin T, Malone Hani R, Kellner Christopher, Bruce Samuel S, Connolly E Sander

Abstract excerpt

BACKGROUND: Phosphodiesterase 4D (PDE4D), through the regulation of cyclic AMP, modulates inflammation and other processes that affect atherosclerosis and stroke. A PDE4D polymorphism, single-nucleotide polymorphism (SNP) 83 (rs966221), is associated with ischemic stroke. The association of SNP 83 with postoperative cognitive dysfunction has never been investigated. OBJECTIVE: To determine whether SNP 83 is...

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PMID: 23863764
DOI: 10.1227/NEU.0000000000000085
PMCID: PMC3935380

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