Article
Inducible nitric oxide synthase promoter polymorphism affords protection against cognitive dysfunction after carotid endarterectomy.
Stroke - 1 May 2009
Yocum Gene T, Gaudet John G, Lee Susie S, Stern Yaakov, Teverbaugh Lauren A, Sciacca Robert R, Emala Charles W, Quest Donald O, McCormick Paul C, McKinsey James F, Morrissey Nicholas J, Solomon Robert A, Connolly E Sander, Heyer Eric J
Abstract excerpt
BACKGROUND AND PURPOSE: Cognitive dysfunction occurs in 9% to 23% of patients during the first month after carotid endarterectomy (CEA). A 4-basepair (AAAT) tandem repeat polymorphism (either 3 or 4 repeats) has been described in the promoter region of inducible nitric oxide synthase (iNOS), a gene with complex roles in ischemic injury and preconditioning against ischemic injury. We investigated whether the...
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