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Article

There is no association between the circadian clock gene HPER3 and cognitive dysfunction after noncardiac surgery.

Anesthesia and analgesia - 1 Aug 2012

Voigt Hansen Melissa, Rasmussen Lars Simon, Jespersgaard Cathrine, Rosenberg Jacob, Gogenur Ismail

Abstract excerpt

BACKGROUND: The specific clock-gene PERIOD3 is important with regard to circadian rhythmicity, sleep homeostasis, and cognitive function. The allele PER3(5/5) has been associated with worse cognitive performance in response to sleep deprivation. We hypothesized that patients with the PER3(5/5) genotype would have an increased risk of postoperative cognitive dysfunction (POCD) 1 week after noncardiac surgery....

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Source

Identifiers

PMID: 22543063
DOI: 10.1213/ANE.0b013e318253d6b3

Genes

PER3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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