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Article

Liquid Biopsy for EGFR Mutation Detection in NSCLC: Evaluation of Plasma ctDNA and Comparison with Plasma exoDNA.

Iranian biomedical journal - 1 Nov 2025

Mashayekhi Parisa, Omrani Mir Davood, Dehghanifard Ali, Khosravi Adnan, Jahani Mohammad Mehdi, Khosravi Negin

Abstract excerpt

Background: Accurate detection of actionable epidermal growth factor receptor ( EGFR) mutations is essential for guiding targeted therapy in non-small cell lung cancer (NSCLC). Liquid biopsy approaches using circulating tumor DNA (ctDNA) and exosomal DNA (exoDNA) offer noninvasive alternatives for molecular profiling. This study evaluated the diagnostic performance of nested PCR combined with sanger sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41420326
DOI: 10.61882/ibj.5018
PMCID: PMC13330677

Genes

EGFR

Variants

Provenance

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