Article
Epidermal growth factor receptor mutations detected by denaturing high-performance liquid chromatography in nonsmall cell lung cancer: impact on response to therapy with epidermal growth factor receptor-tyrosine kinase inhibitors.
Cancer - 15 Sept 2010
Cohen Victor, Agulnik Jason S, Ang Celina, Kasymjanova Goulnar, Batist Gerald, Small David, Brandao Guilherme, Chong George, Miller Wilson H
Abstract excerpt
BACKGROUND: Somatic mutations in the epidermal growth factor receptor (EGFR) kinase domain are associated with sensitivity to EGFR-tyrosine kinase inhibitors (EGFR-TKI) in patients with nonsmall cell lung cancer (NSCLC). METHODS: The authors tested the possibility that nucleotide sequencing may b...
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