Modelling efficiency, error propagation and the effect of error-enhancing drugs in protein synthesis.

Abstract excerpt

The efficiency of protein synthesis is discussed with the main emphasis on the accuracy. The error increase by erroneous synthesizing proteins is studied by a theoretical model which includes the coupling of the amino acylation step to the protein synthesis at the ribosomes. Depending on parameter values, the model yields a stable point of relatively high accuracy, a point where most of the accuracy is lost and...

Topics

• Acylation
• DNA
• Mathematics
• Models, Biological
• Mutation
• Protein Biosynthesis
• RNA, Transfer
• Reproducibility of Results
• Ribosomes
• Transaminases