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Article

Error-prone EF-Tu reduces in vivo enzyme activity and cellular growth rate.

Molecular microbiology - 1 Mar 1991

Hughes D

Abstract excerpt

Mutations in Salmonella typhimurium encoding error-prone EF-Tu (tufA8, tufB103) enhance translational error levels and also cause a reduced growth rate. The relative changes in error level and growth rate are inversely related and dependent on the status of the two tuf genes. Possible causes of the reduced growth rate were investigated. Several important parameters with the potential to alter growth rate (the...

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Identifiers

PMID: 1710757
DOI: 10.1111/j.1365-2958.1991.tb00733.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Error-prone EF-Tu reduces in vivo enzyme activity and cellular growth rate.PMID 1710757Read ↗

A single amino acid substitution in elongation factor Tu disrupts interaction between the ternary complex and the ribosome.Semantic proximity Read ↗

Reducing ppGpp level rescues an extreme growth defect caused by mutant EF-Tu.Semantic proximity Read ↗

Both genes for EF-Tu in Salmonella typhimurium are individually dispensable for growth.Semantic proximity Read ↗

Mutants of the RNA-processing enzyme RNase E reverse the extreme slow-growth phenotype caused by a mutant translation factor EF-Tu.Semantic proximity Read ↗

Connections between translation, transcription and replication error-rates.Semantic proximity Read ↗

Antisuppression by mutations in elongation factor Tu.Semantic proximity Read ↗

EF-Tu from the enacyloxin producing Frateuria W-315 strain: Structure/activity relationship and antibiotic resistance.Semantic proximity Read ↗

Mutants of EF-Tu defective in binding aminoacyl-tRNA.Semantic proximity Read ↗

Suppression of rpsL phenotypes by tuf mutations reveals a unique relationship between translation elongation and growth rate.Semantic proximity Read ↗

Processivity errors of gene expression in Escherichia coli.Semantic proximity Read ↗

Mutation of the conserved Gly83 and Gly94 in Escherichia coli elongation factor Tu. Indication of structural pivots.Semantic proximity Read ↗

Errors of heterologous protein expression.Semantic proximity Read ↗

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