Article
Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites.
Genome research - 1 Nov 2010
Dharia Neekesh V, Plouffe David, Bopp Selina E R, González-Páez Gonzalo E, Lucas Carmen, Salas Carola, Soberon Valeria, Bursulaya Badry, Kochel Tadeusz J, Bacon David J, Winzeler Elizabeth A
Abstract excerpt
Here, we fully characterize the genomes of 14 Plasmodium falciparum patient isolates taken recently from the Iquitos region using genome scanning, a microarray-based technique that delineates the majority of single-base changes, indels, and copy number variants distinguishing the coding regions of two clones. We show that the parasite population in the Peruvian Amazon bears a limited number of genotypes and low...
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