Article
Prediction of quantitative phenotypes based on genetic networks: a case study in yeast sporulation.
BMC systems biology - 10 Sept 2010
Shen Li, Chepelev Iouri, Liu Jie, Wang Wei
Abstract excerpt
BACKGROUND: An exciting application of genetic network is to predict phenotypic consequences for environmental cues or genetic perturbations. However, de novo prediction for quantitative phenotypes based on network topology is always a challenging task. RESULTS: Using yeast sporulation as a model system, we have assembled a genetic network from literature and exploited Boolean network to predict sporulation...
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