Article
Alpha₁-antitrypsin deficiency-related alleles Z and S and the risk of Wegener's granulomatosis.
Arthritis and rheumatism - 1 Dec 2010
Mahr Alfred D, Edberg Jeffrey C, Stone John H, Hoffman Gary S, St Clair E William, Specks Ulrich, Dellaripa Paul F, Seo Philip, Spiera Robert F, Rouhani Farshid N, Brantly Mark L, Merkel Peter A
Abstract excerpt
OBJECTIVE: Deficiency of α(1) -antitrypsin (α(1) AT) may be a determinant of susceptibility to Wegener's granulomatosis (WG). Several previous, mainly small, case-control studies have shown that 5-27% of patients with WG carried the α(1) AT deficiency Z allele. It is not clear whether the S allele, the other major α(1) AT deficiency variant, is associated with WG. This study investigated the relationship of the...
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