Alpha 1-antitrypsin deficiency in Europe: geographical distribution of Pi types S and Z.

doi:10.1016/s0954-6111(98)90278-5

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Article

Alpha 1-antitrypsin deficiency in Europe: geographical distribution of Pi types S and Z.

Respiratory medicine - 1 Mar 1998

Hutchison D C

Abstract excerpt

alpha 1-Antitrypsin (AT) is the principal serum inhibitor of proteolytic enzymes such as neutrophil elastase. AT can exist as over 90 different genetically determined variants known as the Pi system; the three most important variants are type M (90% of population) and types S and Z, two of the co...

Topics

Europe
Gene Frequency
Humans
Phenotype
Prevalence
alpha 1-Antitrypsin Deficiency

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