Article
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Nature - 23 Sept 2010
Heinig Matthias, Petretto Enrico, Wallace Chris, Bottolo Leonardo, Rotival Maxime, Lu Han, Li Yoyo, Sarwar Rizwan, Langley Sarah R, Bauerfeind Anja, Hummel Oliver, Lee Young-Ae, Paskas Svetlana, Rintisch Carola, Saar Kathrin, Cooper Jason, Buchan Rachel, Gray Elizabeth E, Cyster Jason G, Erdmann Jeanette, Hengstenberg Christian, Maouche Seraya, Ouwehand Willem H, Rice Catherine M, Samani Nilesh J, Schunkert Heribert, Goodall Alison H, Schulz Herbert, Roider Helge G, Vingron Martin, Blankenberg Stefan, Münzel Thomas, Zeller Tanja, Szymczak Silke, Ziegler Andreas, Tiret Laurence, Smyth Deborah J, Pravenec Michal, Aitman Timothy J, Cambien Francois, Clayton David, Todd John A, Hubner Norbert, Cook Stuart A
Abstract excerpt
Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from genome-wide association studies alone. Recent advances in rat genomics are facilitating systems-genetics approaches. Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their...
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