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Article

Intermolecular autophosphorylation regulates myosin IIIa activity and localization in parallel actin bundles.

The Journal of biological chemistry - 12 Nov 2010

Quintero Omar A, Moore Judy E, Unrath William C, Manor Uri, Salles Felipe T, Grati M'hamed, Kachar Bechara, Yengo Christopher M

Abstract excerpt

Myosin IIIa (Myo3A) transports cargo to the distal end of actin protrusions and contains a kinase domain that is thought to autoregulate its activity. Because Myo3A tends to cluster at the tips of actin protrusions, we investigated whether intermolecular phosphorylation could regulate Myo3A biochemical activity, cellular localization, and cellular function. Inactivation of Myo3A 2IQ kinase domain with the point...

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Identifiers

PMID: 20826793
DOI: 10.1074/jbc.M110.144360
PMCID: PMC2975201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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