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Article

Rapid Induction of Androgen Receptor Splice Variants by Androgen Deprivation in Prostate Cancer

21 Jan 2014

Abstract excerpt

PURPOSE: Mechanisms mediating androgen receptor (AR) reactivation in prostate cancer that progresses after castration (castration-resistant prostate cancer; CRPC) and subsequent treatment with abiraterone (CYP17A1 inhibitor that further suppresses androgen synthesis) remain unclear. EXPERIMENTAL DESIGN: Prostate cancer xenografts were examined to identify mechanism of progression after castration and abiraterone....

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Identifiers

PMID: 24449822
DOI: 10.1158/1078-0432.ccr-13-1863

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